Principal Scientist, Early In Process Analytics, Mammalian Expression Technology CoE
GlaxoSmithKline
Posted Saturday, September 28, 2024
Posting ID: 405480
Cambridge, MA
Principal Scientist, Early In-Process Analytics, Mammalian Expression Technology CoE
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.
We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.
In the plan to create a new hub for mRNA-based vaccine discovery and CHO recombinant protein vaccine early development in Cambridge, we are building new laboratories that will be focused on the development of state-of-the-art methods that will be supporting deep product understanding, process and product development, as well as testing of pre-clinical and clinical samples for new mRNA and CHO protein-based vaccines. Situated in Cambridge-based hub, Mammalian Expression Technology Center of Excellence (MET CoE), Technical Research & Development, GSK Vaccines R&D is responsible for the development of CHO based production cell lines, next-gen cell line engineering and baseline upstream process for innovative recombinant protein/adjuvanted vaccine projects and platforms.
Key Responsibilities:
As a Principal Scientist, Early In-Process Analytics, Mammalian Expression Technology CoE, you will be expected to take on the main core responsibilities as listed below:
Drive the design, development and implementation of in-process analytical methods (content, potency and process, and product-related impurities) to support cell line and early process development projects as well as next-gen cell line engineering. Technical leader/Subject matter expertise representing DS to collaborate proactively with preclinical/discovery teams and late-stage in-process analytic group to support antigen selection and early product understanding workflows to enable swift CMC onboarding and transferring. Lead the assessment and implementation of novel in-process analytical techniques to support acceleration of project delivery and CMC submissions.
The candidate is also expected to spend few months (from 3 to 6 months) within the first year in Rockville. MD (Washington DC area) to support and ensure a smooth transition of the methods and the knowhow to the new laboratories in Cambridge.
Basic Qualifications:
#Li-GSK
Please visit GSK US Benefits Summary t o learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.
We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.
In the plan to create a new hub for mRNA-based vaccine discovery and CHO recombinant protein vaccine early development in Cambridge, we are building new laboratories that will be focused on the development of state-of-the-art methods that will be supporting deep product understanding, process and product development, as well as testing of pre-clinical and clinical samples for new mRNA and CHO protein-based vaccines. Situated in Cambridge-based hub, Mammalian Expression Technology Center of Excellence (MET CoE), Technical Research & Development, GSK Vaccines R&D is responsible for the development of CHO based production cell lines, next-gen cell line engineering and baseline upstream process for innovative recombinant protein/adjuvanted vaccine projects and platforms.
Key Responsibilities:
As a Principal Scientist, Early In-Process Analytics, Mammalian Expression Technology CoE, you will be expected to take on the main core responsibilities as listed below:
Drive the design, development and implementation of in-process analytical methods (content, potency and process, and product-related impurities) to support cell line and early process development projects as well as next-gen cell line engineering. Technical leader/Subject matter expertise representing DS to collaborate proactively with preclinical/discovery teams and late-stage in-process analytic group to support antigen selection and early product understanding workflows to enable swift CMC onboarding and transferring. Lead the assessment and implementation of novel in-process analytical techniques to support acceleration of project delivery and CMC submissions.
The candidate is also expected to spend few months (from 3 to 6 months) within the first year in Rockville. MD (Washington DC area) to support and ensure a smooth transition of the methods and the knowhow to the new laboratories in Cambridge.
Basic Qualifications:
- Ph.D in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 3+ years relevant experience; MS in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 6+ year relevant experience; BS in Biochemistry, Molecular Biology, Chemical Engineering, Biotechnology or Bioengineering with 9+ year relevant experience.
- 2+ years of hands-on experience with development and implementation of state-of-art multiplex immuno analytics, e.g. ELISA, Octet, Biacore, Luminex and MSD for complex protein or biologics based drug substance characterization.
- 1+ year hands-on solid experience with state-of-art molecular analytics, e.g. real-time PCR, digital droplet PCR and NGS.
- Extensive experience with Quality by Design with demonstrated capability to develop fit-for-purpose high throughput in process analytics to support cell line development and cell line engineering.
- Experiences with advanced NGS and Omics-techniques for transgene copy number/integrity/structure variant characterization.
- Advanced knowledge of structural biology and protein engineering.
- Experience in High throughput technologies (eg. Liquid Handling systems such TECAN).
#Li-GSK
Please visit GSK US Benefits Summary t o learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).
GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.
Important notice to Employment businesses/ Agencies
GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.
Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.
The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.