Associate Scientist I Downstream PD

Description:

Development, optimization, characterization, scale-up and technical transfer of GMP-compliant manufacturing processes for recombinant viral vectors. This position requires broad scientific understanding and hands-on execution of a variety of downstream, harvest and purification unit operations, with a focus on depth and membrane filtration and TFF

What you’ll be doing

• Contributes to the development of robust, high-yielding, scalable and economically viable purification processes for the production of AAV products using bench scale and pilot scale disposable downstream equipment

• Contributes to experimental design

• Executes experiments and contributes to data analysis and interpretation

• Contribute to process scale-up and support GMP operations through technology transfer and process troubleshooting

• Contributes to the evaluation and implementation of new methods, techniques, equipment and technology platforms

• Coordinates with relevant groups in technical operations and research and development

• Performs standard analytical methods to characterize biologics - HPLC, SDS-PAGE, Western Blot, protein assays, spectrophotometer.

• Active participation in daily maintenance of laboratory equipment

• Embody company core values by working collaboratively building strong relationships, and using clear communication to meet shared objectives

• Ability to travel up to 10% of the time

Additional Skills & Qualifications:

 Bachelor’s degree in relevant scientific discipline with at least 2+ years relevant industry experience or master’s degree in relevant scientific discipline with 1+ year of relevant industry experience in GMP manufacturing, Quality or Process Development

 Hands on experience with Chromatography (ion exchange, hydrophobic interaction, mixed mode, affinity, etc.), and Filtration; depth filters for clarification, membranes in normal flow (NF) and Tangential Flow Filtration (TFF)

 Familiar with purification scale-up and/or tech transfer concepts

 Ability to perform routine analysis on moderately complex datasets

 Familiar with good lab practices including equipment maintenance and use of biochemical analytical tools

 Intermediate computer skills using MS Office

 Ability to perform assigned experiments and independently perform routine activities

 Ability to process data into meaningful representations

 Ability to understand the experimental process and objectives in order to recognize atypical results

 Ability to perform basic/routine data analysis

 Ability to communicate information and results in appropriate format (lab notebook, presentations)

 Work collaboratively and effectively as part of team