Senior Scientist, Analytical Research and Development - Onsite
Merck & Co., Inc
Posted Thursday, April 16, 2026
Posting ID: MERCUSR393639FRCA
Rahway, NJ
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Job Description
The Materials and Biophysical Characterization group in Analytical Research and Development is seeking a highly self-motivated and innovative scientist with deep knowledge and problem-solving skills in biotherapeutics characterization. The Materials and Biophysical Characterization team is responsible for building the mechanistic understanding of the interplay between formulation composition, stability, device, and process to ensure robustness and quality of drug substances and drug products in the biotherapeutics pipeline.
As a Senior Scientist, you will be contributing to projects in a diverse biotherapeutics pipeline by developing and implementing biophysical and particle characterization assays and collaborating with process, formulation and device functions as part of the CMC development team. You are expected to use your scientific expertise to find creative solutions to challenging problems which require deep analytical insight and critical thinking. Additional responsibilities include authoring technical reports and regulatory documents, presenting technical data, and project management. You will have the opportunity to conduct independent research, publish research findings, present at scientific conferences, and engage with various external scientific societies/organizations. This is an excellent growth and learning opportunity to work in an exciting, collaborative environment with a wide array of scientists from different divisions and make significant contributions towards our life-saving medicines.
Education Minimum Requirement:
Analytical Method Development, Assay Development, Bioanalytical Analysis, Biochemical Assays, Biochemistry, Chemical Biology, Chromatographic Techniques, Differential Scanning Calorimetry (DSC), Dynamic Light Scattering Analysis, Flow Cytometry, Infrared Spectroscopy, Innovative Thinking, Protein Interactions, Strategic Thinking, Technical Writing, Ultra Performance Liquid Chromatography (UPLC)
Preferred Skills:
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as remote".
The salary range for this role is
$117,000.00 - $184,200.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits .
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
1st - Day
Valid Driving License:
No
Hazardous Material(s):
No
Job Posting End Date:
04/30/2026
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R393639
The Materials and Biophysical Characterization group in Analytical Research and Development is seeking a highly self-motivated and innovative scientist with deep knowledge and problem-solving skills in biotherapeutics characterization. The Materials and Biophysical Characterization team is responsible for building the mechanistic understanding of the interplay between formulation composition, stability, device, and process to ensure robustness and quality of drug substances and drug products in the biotherapeutics pipeline.
As a Senior Scientist, you will be contributing to projects in a diverse biotherapeutics pipeline by developing and implementing biophysical and particle characterization assays and collaborating with process, formulation and device functions as part of the CMC development team. You are expected to use your scientific expertise to find creative solutions to challenging problems which require deep analytical insight and critical thinking. Additional responsibilities include authoring technical reports and regulatory documents, presenting technical data, and project management. You will have the opportunity to conduct independent research, publish research findings, present at scientific conferences, and engage with various external scientific societies/organizations. This is an excellent growth and learning opportunity to work in an exciting, collaborative environment with a wide array of scientists from different divisions and make significant contributions towards our life-saving medicines.
Education Minimum Requirement:
- Ph.D. in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline
- M.S. in Biophysics, Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences or related discipline with a minimum 4 years of relevant industry experience.
- Experience in the analysis of biologics, protein/peptide stability, protein-protein interactions
- Experience with subvisible and submicron particle characterization tools (e.g. flow imaging microscopy, backgrounded membrane imaging (BMI), flow cytometry, dynamic light scattering (DLS))
- Hands-on experience in biophysical characterization of proteins and peptides (e.g. Circular Dichroism (CD), Infrared Spectroscopy (IR), Differential Scanning Calorimetry (DSC), Analytical Ultracentrifugation (AUC))
- Understanding of protein aggregation mechanisms and link between analytical methodologies for analysis
- Ability to deliver complex objectives under aggressive timelines in a rapidly changing environment
- Demonstrated ability for taking initiative, creativity, and innovative problem solving.
- A strong team player with excellent oral and written communication skills; ability to work both independently and cross-functionally
- Experience with characterization of lyophilized protein formulations
- Experience with Small Angle Xray Scattering
- Experience with molecular modeling.
- Experience with biological formulation development and analytical method development.
- Experience with various biologics modalities including peptides, mAbs, ADC, fusion proteins
Analytical Method Development, Assay Development, Bioanalytical Analysis, Biochemical Assays, Biochemistry, Chemical Biology, Chromatographic Techniques, Differential Scanning Calorimetry (DSC), Dynamic Light Scattering Analysis, Flow Cytometry, Infrared Spectroscopy, Innovative Thinking, Protein Interactions, Strategic Thinking, Technical Writing, Ultra Performance Liquid Chromatography (UPLC)
Preferred Skills:
Current Employees apply HERE
Current Contingent Workers apply HERE
US and Puerto Rico Residents Only:
Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.
As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:
EEOC Know Your Rights
EEOC GINA Supplement
We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively.
Learn more about your rights, including under California, Colorado and other US State Acts
U.S. Hybrid Work Model
Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as remote".
The salary range for this role is
$117,000.00 - $184,200.00
This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee's position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.
The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits .
You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.
San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance
Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance
Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.
Employee Status:
Regular
Relocation:
Domestic
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
1st - Day
Valid Driving License:
No
Hazardous Material(s):
No
Job Posting End Date:
04/30/2026
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.
Requisition ID:R393639
Compensation:$117,000 - $184,200 / yr
The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.
On-SiteWritingSelf-MotivationBiopharmaceuticalsProject ManagementInnovationResearchDynamic Light ScatteringProblem SolvingCritical ThinkingCreativityTelecommutingProactivityChemistryBiochemistryAssay DevelopmentBiochemical AssaysBiologyRegulatory DocumentsContingent WorkforceTechnical WritingTelephone SkillsChemical EngineeringStrategic ThinkingCompassionBiomedical EngineeringCalorimetryFlow CytometryMicroscopySpectroscopyChromatographyWritten CompositionBody Mass Index (BMI)Protein CharacterizationMolecular ModelingPharmaceutical SciencesMonoclonal AntibodiesLyophilizationBiophysicsChemical BiologyProtein-Protein InteractionsAnalytical UltracentrifugationAnalytical MethodChromatographic Techniques
